Patient challenges
with dilation

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Dilation is a crucial but often disruptive approach to protecting eye health^1-4

Mydriasis can lead to blurred vision, difficulty focusing on nearby objects, and light sensitivity.⁵

Depending on the pharmacological drop used, iris pigmentation, age, and other factors, mydriasis can last anywhere from 6-24 hours.⁵

Waiting hours for vision to clear can lead to patient frustration and refusal of dilation.^5-9

Accelerated mydriatic reversal may allow individuals to return to their activities, such as:

Using electronic
devices^5,10-12

Driving^5,10-12

Reading^5,10-12

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Ryzumvi

Important Safety Information

Warnings and Precautions

Uveitis: RYZUMVI is not recommended to be used in patients with active ocular inflammation (e.g., iritis).
Potential for Eye Injury or Contamination: To avoid the potential for eye injury or contamination, care should be taken to avoid touching the vial tip to the eye or to any other surface.
Use with Contact Lenses: Contact lens wearers should be advised to remove their lenses prior to the instillation of RYZUMVI and wait 10 minutes after dosing before reinserting their contact lenses.

Adverse Reactions

The most common adverse reactions that have been reported are instillation site discomfort (16%), conjunctival hyperemia (12%), and dysgeusia (6%).

Indication

RYZUMVI® (phentolamine ophthalmic solution) 0.75% is indicated for the treatment of pharmacologically-induced mydriasis produced by adrenergic agonists (e.g., phenylephrine) or parasympatholytic (e.g., tropicamide) agents.

Click here for full Prescribing Information.

References: 1. Boyd K. Mendoza O. What are dilating eye drops? American Academy of Ophthalmology. Available at: https://www.aao.org/eye-health/drugs/dilating-eyedrops. Accessed February 8, 2024. 2. American Academy of Ophthalmology. Comprehensive adult medical eye evaluation preferred practice pattern. American Academy of Ophthalmology. 2020;1-29. 3. Paremyd. Prescribing Information. Akorn, Inc. 2001. 4. Tropicamide. Prescribing Information. Alcon Laboratories, Inc. 2022. 5. Pepose JS, et al. Reversal of pharmacologically induced mydriasis with phentolamine ophthalmic solution. Ophthalmology. 2024. https://doi.org/10.1016/j.ophtha.2024.09.010. 6. Murphy J. How often do you dilate? Review of Optometry. Available at: https://www.reviewofoptometry.com/article/how-often-do-you-dilate. Accessed February 8, 2024. 7. American Optometric Association. 2 points to keep in mind when patients decline dilation. Available at: https://www.aoa.org/news/practicemanagement/billing-and-coding/2-points-to-keep-in-mind-when-patients-decline-dilation? Accessed February 8, 2024. 8. AAPOS Online 2024: How long do dilating drops last? Available at: https://www.aapos.org/glossary/dilating-eye-drops#:~:text=nearsightedness%20(myopia).-,HOW%20LONG%20DO%20DILATING%20DROPS%20LAST%3F,from%204%20to%2024%20hours. Accessed January 15, 2025. 9. Mayo Clinical Online 2024: Drugs and Supplements Hydroxyamphetamine and Tropicamide (Ophthalmic Route). Available at: https://www.mayoclinic.org/drugs-supplements/hydroxyamphetamine-and-tropicamide-ophthalmic-route/description/drg-20061972. Accessed January 15, 2025. 10. Goel S, Maharajan P, Chua C, Dong B, Butcher M, Bagga P. Driving ability after pupillary dilation. Eye. 2003;17(6):735-738. 11. Siderov J, Bartlett JR, Madigan CJ. Pupillary dilation: the patient’s perspective. Clin Exp Optom. 1996;79(2):62-66. 12. Adediji AK, Adio AO, Fiebai B. Effects of diagnostic mydriasis on distant and near vision. IOSR J Dent Med Sci. 2019;18(3):45-49.

Patient challengeswith dilation

Dilation is a crucial but often disruptive approach to protecting eye health1-4

Depending on the pharmacological drop used, iris pigmentation, age, and other factors, mydriasis can last anywhere from 6-24 hours.5

Accelerated mydriatic reversal may allow individuals to return to their activities, such as:

Important Safety Information

Warnings and Precautions

Adverse Reactions

Indication

Important Safety Information

Warnings and Precautions

Adverse Reactions

Indication

Patient challenges
with dilation

Dilation is a crucial but often disruptive approach to protecting eye health^1-4

Depending on the pharmacological drop used, iris pigmentation, age, and other factors, mydriasis can last anywhere from 6-24 hours.⁵